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| Caption | Generation of the Fgfr2tm2Ewj (Fgfr2 P253R) allele. A) Targeting construct created with a TK cassette, neo cassette with flanking loxP sequences, and a portion of the wild-type Fgfr2 gene (including exons IIIa, IIIb, and IIIc, but not exon 10) introduced by Hind III (H) digestion; mutant allele produced by homologous recombination and neo deletion mediated by Cre. The 758C>G, P253R mutation (*) was introduced into exon IIIa. Probes (-) and restriction enzyme Sty I (St) or Sac I (S) used for Southern blot analysis and PCR primers (F, Fn, R arrows) for genotyping are shown. The neo cassette can be deleted via cre-mediated recombination. | ||||
| Copyright | This image is from Wang Y, BMC Dev Biol 2010;10():22, an open-access article, licensee BioMed Central Ltd. J:158773 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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