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| Caption | Generation of the Tsc2tm1Kcess (Tsc2neo.flox) allele. (A) Schematic representation of targeting vector with homologous left 6.8-kb and right 5.3-kb arms. Tsc2 genomic structure and targeted allele Tsc2tm1Kcess (Tsc2neo.flox) containing the PGK-neo cassette flanked by Frt sites (red arrowheads) and loxP sites flanking exons 36 and 37 that encode critical residues of the GAP domain. An additional EcoRI site to aid in genotyping was also added immediately 5' to the loxP site. Select regions have been expanded to highlight PCR primer sites. | ||||
| Copyright | This image is from Fu C, Genesis 2013 Apr;51(4):284-92, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:195049 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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