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| Caption | Generation of the Muc19tm2Culp allele. A, strategy for targeted disruption of Muc19 transcripts from the gene Muc19. The homology arms were inserted into the selection cassette PGKneolox2DTA that encodes for neomycin under control of the PGK promoter. The PGKneo sequence is flanked by loxP sites (not shown). The sequence from the STOP cassette, pBS302, was inserted between the downstream loxP site, and diphtheria toxin A was driven by the PGK promoter for negative selection. The targeted allele is shown with restriction sites (PvuII and SphI) and probes used for Southern blot analyses as well as sites of PCR primers w-z. | ||||
| Copyright | This image is from Das B, J Biol Chem 2013 May 24;288(21):14742-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199625 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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