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| Caption | Schematic of the spontaneous Muc19sld mutation. Map of genomic sequencing strategy, resultant sequence variations and minigene splicing assays of the 3'-end mutations. A, genomic sequencing of Muc19/Smgc incorporated either cloned PCR products (black numbered boxes) or PCR products (gray numbered boxes). Three insertion mutations in introns 18, 53, and 57 are indicated by gray arrows. Because we were unable to sequence through TA repeats within intron 52, we label this region as a potential mutation site with unknown TA repeats. The central region of exon 50 is intractable to both cloning and sequencing because its central region contains ~36 tandem repeats of 489 bp that encode Ser/Thr-rich sequences. | ||||
| Copyright | This image is from Das B, J Biol Chem 2013 May 24;288(21):14742-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199625 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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