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| Caption | (B) Schematic representation of the gene-targeting strategy to generate a conditional Edn2tm1.1Nat allele. The initial gene targeting product in which exon 2 is flanked by loxP sites (open triangles) and is followed by FRT (filled triangles)-flanked PGK-neo (ET-2neo-loxP); the targeted allele following FRP-mediated excision of the PGK-neo cassette (Edn2tm1.1Nat; ET-2flox/flox); an ET-2 conditional null allele can be obtained by Cre-mediated excision of exon 2 (ET-2-/-). Dashed lines show site-specific recombination events. Position of the Southern blot probe is shown as probe. The predicted lengths of the EcoRI restriction fragments are shown above each of the alleles. PGK, phosphoglycerine kinase; E, EcoRI. (C) Southern blot hybridization of EcoRIdigested genomic DNA showing hybridization patterns for the four alleles illustrated in panel B. | ||||
| Copyright | This image is from Chang I, J Clin Invest 2013 Jun 3;123(6):2643-53 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201436 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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