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| Caption | (Top) Schematic of the Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa transgene construct. BGH PA = bovine growth hormone poly adenylation signal, cHS4 = chicken hyper sensitive region 4 insulator fragment (+/- refers to opposite orientations), SYN1 = human SYN1 promoter, Hexb= Hexb coding sequence, SV40 PA = simian virus 40 poly adenylation signal, TRE-CMVdelta = tet responsive element - cytomegalovirus minimal promoter (TRE-Tight), tTA2s = tet-transactivator coding sequence (tet-off). (Bottom) Expression of transgenic Hexb from a single autoregulatory cassette was driven by the human SYN1 promoter. Tet-transactivator expressed from the tTA2s coding sequence promoted expression of Hexb cDNA from tet-response elements (TRE). This was inhibited by doxycycline. | ||||
| Copyright | This image is from Sargeant TJ, PLoS Genet 2012 Sep;8(9):e1002943, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:190450 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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