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| Caption | Generation of the Sox11tm1.1Gan allele. A, schematic representation of a portion of the wild-type Sox11 allele, the targeting construct and the targeted alleles. Gray-filled box is the open reading frame (ORF) of Sox11. Black-filled boxes are the sequences used to generate the homologous arms in the targeting vector. The Sox11CKO targeting vector is made by inserting the FRT-flanked neomycin gene and one loxP site before the ORF of Sox11. Cre recombinase-mediated deletion of the loxP-flanked Sox11 ORF results in a Sox11-null mutation. Blue-filled box is the 5' hybridization probe used for Southern blot analysis. Abbreviations: Neo, PGK-neomycin resistance gene; DTA, diphtheria toxin gene for negative selection of embryonic stem cells; loxP, Cre recombinase recognition sequence. | ||||
| Copyright | This image is from Jiang Y, J Biol Chem 2013 Jun 21;288(25):18429-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199663 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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