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| Caption | Strategy for the generation of the Atat1tm1(KOMP)Vlcg allele. Pink boxes denote the 5'- and 3'-untranslated sequences, and solid boxes indicate exons of the Atat1 gene located at the mouse chromosome 17qB1 (UCSC Genome Browser). A Bac targetingvector was utilized to replace the 9.2-kb genomic sequence of Atat1, spanning the entire coding region, with the promoterless lacZ coding sequence and a ubiquitin C (UBC) promoter-neomycin selection cassette flanked by two LoxP sites. SA, splicing acceptor; pA, poly-adenylation signal. Rough positions of the PCR genotyping primers are indicated with tiny bars; F1 and R1 are for amplifying a 321-bp fragment from wild-type (WT) allele, and InF and InR are used to amplify a 210-bp fragment from the knock-out allele. | ||||||
| Copyright | This image is from Kim GW, J Biol Chem 2013 Jul 12;288(28):20334-50 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:201922 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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