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| Caption | Generation of Spo11tm1Bdm (Spo11 Y138F) allele. (A) Intron/exon structure of the Spo11 gene. Step 1: homologous recombination using a NotI fragment that replaces exons 5-9 and part of the flanking introns for a HYG/TK positive/negative selectable marker cassette and two heterologous lox sites, loxC33 and lox511. Step II: Cre-mediated cassette exchange using a donor plasmid that replaces the HYG/TK cassette for a mutated Spo11 fragment carrying the F138 codon in exon 5. | ||||
| Copyright | This image is from Carofiglio F, PLoS Genet 2013 Jun;9(6):e1003538, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199075 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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