Molecular Image Detail

Image

Caption

Generation of the Ass1^tm1.1Ekoe and Ass1^tm1.2Ekoe alleles. Panel A: Schematic representation of the Ass1-targeting construct (AscI - PmeI). The AscI and PmeI sites flanking the construct (14.38 Kb) were introduced by PCR. The XmnI and EcoRI sites upstream from the recombination arms of the targeting construct were used for Southern-blot characterization. (C) Wild-type exon-13 allele, Ass1^tm1.1Ekoe (floxed) allele, and Ass1^tm1.2Ekoe (knock-out) allele, together with remnant frt and loxP sites. F1, F2, and R1 indicate the position of the primers used to identify these genotypes.

This image is from Marion V, PLoS One 2013;8(6):e67021, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:203474

Associated
Alleles

Symbol	Name
Ass1^tm1.1Ekoe	argininosuccinate synthetase 1; targeted mutation 1.1, Eleonore Kohler
Ass1^tm1.2Ekoe	argininosuccinate synthetase 1; targeted mutation 1.2, Eleonore Kohler

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