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Molecular Image Detail
Image
Caption (A) Schematic of the HTRA1 knockout strategy to generate the Htra1tm1.1Pfi allele. Primers were designed with one forward primer (For) that amplifies an amplicon for the wild-type and heterozygous alleles with a corresponding reverse primer (Rev), and a second reverse primer designed to only amplify the knockout. The knockout reverse primer (KO Rev) only amplifies following CRE-LOX recombination. Solid triangles = loxP sites; EV = EcoRI. E2 = Exon 2; E3 = Exon 3.
Copyright This image is from Graham JR, PLoS One 2013;8(9):e74094, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:206395
Associated
Alleles
Symbol Name
Htra1tm1.1Pfi HtrA serine peptidase 1; targeted mutation 1.1, Pfizer, Ltd

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory