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| Caption | A. Schematic genomic diagram of the targeting strategy to generate the Gtf2itm1Vcam allele. A. Partial restriction map of wild-type genomic DNA encompassing exons 1 (grey box), 2, 3, 4 and 5 of the Gtf2i locus (filled boxes) (B, BamHI; E, EcoRI; Bg, BglII); the translation initiator sites in the wild-type (*) and targeted (**) alleles are indicated. The arrows indicate the location of the primers used for RT-PCR analysis. The targeting vector contains the PGK-neo (open box, neo) and lox511 sequences (filled triangle). Predicted targeting allele after homologous recombination. The stippled box indicates the location of the probe used for Southern blot analysis, recognizing EcoRI DNA fragments of 14,7kbp (wild-type allele) and 9,7kbp (targeted allele). | ||||
| Copyright | This image is from Lucena J, BMC Med Genet 2010;11():61, an open-access article, licensee BioMed Central Ltd. J:204278 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/09/2024 MGI 6.24 |
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