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| Caption | Generation of the Topbp1tm1.1Zqw allele. (A) Schematic of the C-terminus of the Topbp1 locus: wild-type (wt), targeted (tg) and Topbp1tm1.1Zqw knock-in (ki) alleles. The red line marks the targeting vector. Exons are numbered in the boxes, Southern blot probes (p8 and p5), sizes of DNA fragments after indicated enzyme digestion and the location of primers for PCR genotyping are shown. The targeting vector contained a neomycin resistance gene (Neo) flanked by two frt sites (grey triangles). Exon 20 is flanked by two loxP sites (black triangle). Tryptophan 1147 (W1147) was mutated into arginine in AAD by replacing T3439 with C in exon 20. | ||||
| Copyright | This image is from Zhou ZW, PLoS Genet 2013 Aug;9(8):e1003702, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:200981 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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