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Molecular Image Detail
Image
Caption (A) Gene targeting of Trpv4 and genetic manipulation underlying generation of the Trpv4tm1.1Ldtk allele. Shown are sequential steps of mouse Trpv4 targeting, starting with flanking Trvp4 exon13 with loxP elements and insertion of a selection cassette, flanked by frt sites, in mouse ES cells. After generation of chimeric mice and stable transmission of the engineered mutation, the selection cassette was removed by breeding to FLPe mice. Cre-mediated recombiantion can be utilized to generate conditional mutants.
Copyright This image is from Moore C, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):E3225-34. Copyright 2013 National Academy of Sciences, U.S.A. J:200749
Associated
Alleles
Symbol Name
Trpv4tm1.1Ldtk transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1.1, Wolfgang Liedtke
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory