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| Caption | Generation of the Mylktm1.1Bph and Mylktm1.2Bph alleles. A, Schematic representation of the approach used to delete the intronic CArG region from the endogenous Mylk gene. The native Mylk gene is shown at the top with the targeting vector below it. The numbers above the native gene refer to nucleotide positions relative to the transcription start site of the 130-kDa smMLCK. The promoter and intronic CArG boxes are indicated (red and blue boxes, respectively). Yellow triangles, loxP sites; black triangles, FRT sites. Below the targeting vector are schematic representations of the correctly targeted allele (Flox + Neo), the targeted allele following FLP mediated removal of the neomycin cassette (Flox; Mylktm1.1Bph), and the deleted allele generated following Cre-mediated recombination (Deleted allele; Mylktm1.2Bph). Positions of primers used for genotyping are indicated. | ||||||
| Copyright | This image is from Chen M, J Biol Chem 2013 Nov 29;288(48):34647-57 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:204964 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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