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| Caption | Generation of the Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs (LMP1/CD40flSTOP) allele. (A) Targeting strategy for the insertion of a conditional allele into the murine ROSA26-locus. Cre-mediated recombination leads to deletion of the stop cassette and expression of Lmp1/CD40 under transcriptional control of the endogenous ROSA26-promoter. The scheme of the targeting construct shows the EcoRI recognition sites and the location of the probe. The expected fragments after EcoRI digestion and hybridization with the labeled probe are indicated by the thin lines. SAS, splice acceptor site; STOP, Stop cassette, XbaI, site of insertion. | ||||
| Copyright | This image is from Homig-Holzel C, J Exp Med 2008 Jun 9;205(6):1317-29, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:137122 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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