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| Caption | Generation of human Tnfrsf1a knockin mice (Tnfrsf1-alpha "humanized" mice), Tnfrsf1atm4.1(TNFRSF1A)Gkl. A: Genomic structure of the wild-type mouse Tnfrsf1a locus. E and Nc refer to EcoRI and NcoI restriction sites respectively. B-C: Homologous recombination of the targeting vector allows the generation of a "humanized" Tnfrsf1a locus that is shown before (B) and after (C) neoR gene deletion. Exons are represented by boxes. Grey lines and boxes represent human sequences, black represent mouse sequences. | ||||
| Copyright | This image is from Van Hauwermeiren F, J Clin Invest 2013 Jun 3;123(6):2590-603 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:210950 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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