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| Caption | The strategy used to generate the Zeb2tm2.1Yhi knock-in allele by gene targeting. The targeting vector encodes EGFP (green box) fused to the ZEB2 (SIP1) protein carboxy terminus. The loxP-flanked neomycin (neo) selection cassette introduced into intron 8 was eventually removed by cre recombinase. The XbaI (X) sites and the expected length of the extra bands on a Southern blot that correspond to the desired homologs recombination are denoted by the red letters and lines. The 5' and 3' external probes are indicated by transparent gray bars. The light blue and open boxes denote the Zeb2 coding and noncoding exons, respectively. The dark blue triangles indicate loxP sequences. The triangles (designated P1, P2, and P3) indicate the primers used for genotyping of the Zeb2tm2.1Yhi allele. | ||||
| Copyright | This image is from Nishizaki Y, Genesis 2014 Jan;52(1):56-67, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:207850 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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