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| Caption | (A) Diagram of the targeting strategy for generation of Ntrk1tm1.1Azmo allele. Schematic structures of Ntrk1 (TrkA) Ntrk1 genomic locus (top), of Ntrk1 locus after homologous recombination (middle) and after neo cassette excision (bottom) are shown. The extracellular part of the Ntrk1/Ntrk3 (TrkAC) chimeric protein is encoded by first 10 exons of the endogenous Ntrk1 (TrkA) in order to ensure proper expression of the Ntrk1/Ntrk3 (TrkAC) mRNA. The transmembrane and intracellular parts of Ntrk1/Ntrk3 (TrkAC) protein are encoded by Ntrk3 (TrkC) cDNA. An IRES allows Cherry expression in Ntrk1/Ntrk3 (TrkAC)-expressing neurons. Selection marker neo is flanked by loxP site (triangles) and is removed by crossing to a mouse expressing ubiquitous Cre recombinase. Positions of HincII restriction enzymes as well as locations of external and neo probes are shown. P1, P2, P3 are primers used in genotyping strategy of tail PCR. | ||||
| Copyright | This image is from Gorokhova S, PLoS Genet 2014 Feb;10(2):e1004081, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:210892 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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