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| Caption | Generation of the Svoptm1Baj and Svoptm1.1Baj alleles. Shown is the strategy used to generate mice lacking SVOP. A) An 11.4kb genomic DNA containing exons 2-5 of the SVOP gene was used for generating a targeting construct. B) A targeting construct was generated in which exons 2 and 3 were flanked by Cre recombinase recognition (loxP) sites. A cDNA encoding neomycin resistance protein was included to allow screening of embryonic stem cells. To allow removal of the neomycin resistant gene, it was flanked by Flipper recombinase recognition (Frt) sites. C) Map of the targeted gene generated by homologous recombination. D) Upon Cre recombinase induced excision, exons 2 and 3 are removed. This results in a truncated protein after the codon encoding a.a.18. | ||||||
| Copyright | This image is from Yao J, PLoS One 2013;8(7):e68215, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:204383 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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