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| Caption | Generation of Generation of the Camta1tm1.1Eno and Camta1tm1.2Eno alleles. Functional domains of CAMTA1 and the corresponding exonic structures are shown. Exon 9, which encodes a major portion of the transactivation domain (TAD), was deleted to create a null allele, CAMTA1neo-loxP, by homologous recombination in ES cells. The neomycin cassette flanked by FRT sites was removed by breeding to FLPe transgenic mice, generating the Camta1tm1.1Eno (CAMTAfl) allele. The CAMTA1-null (Camta1tm1.2Eno) allele was generated through Cre-mediated excision. Positions of primers (P1, P2, and P3) and probes used for genotyping are shown. Forward and reverse primers for RT-PCR are indicated as F-RT and R-RT, respectively. The mutant allele would generate a truncated protein containing 284 amino acids, as schematized at the bottom. | ||||||
| Copyright | This image is from Long C, Proc Natl Acad Sci U S A 2014 Aug 5;111(31):11521-6. Copyright 2014 National Academy of Sciences, U.S.A. J:212232 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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