Molecular Image Detail

Image

Caption

Generation of the Hsp90b1^tm1.1Alee and Hsp90b1^tm1.2Alee alleles. (A) Schematic drawings of the Grp94 exon map, the wild-type (WT) allele, the loxP-FRT targeting vector, the Floxed (F) allele (Hsp90b1^tm1.1Alee) and the KO (Hsp90b1^tm1.2Alee) allele. The ATP-binding domain of GRP94, the insertion positions of neo cassette, the loxP (closed triangle) and FRT (open triangle) sites, and the pgk-TK expression cassette are indicated. The BamHI restriction digestion sites, the position of the 5'-probe for Southern blotting, the expected location and size for both the Southern blot products and the genotyping products are also indicated.

This image is from Mao C, PLoS One 2010;5(5):e10852, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160900

Associated
Alleles

Symbol	Name
Hsp90b1^tm1.1Alee	heat shock protein 90, beta (Grp94), member 1; targeted mutation 1.1, Amy Lee
Hsp90b1^tm1.2Alee	heat shock protein 90, beta (Grp94), member 1; targeted mutation 1.2, Amy Lee

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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