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| Caption | Generation of the Gt(ROSA)26Sortm1(ITK/SYK)Jrld allele. (A) Schematic representation of the gene-targeting strategy. A targeting vector that carries the human ITK-SYK cDNA together with an IRES eGFP sequence preceded by a loxP-flanked NEO-STOP cassette was constructed and used to generate Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+ (Rosa26loxSTOPlox-ITK-SYK) mice. The recombinant Rosa26 locus and the ITK-SYK expressing locus upon Cre-mediated deletion of the NEO-STOP cassette are indicated. SA, splice acceptor site; pA, polyA sequence; 1-3, Rosa26 exon 1-3; probe, flanking probe for Southern blot analysis. | ||||
| Copyright | This image is from Pechloff K, J Exp Med 2010 May 10;207(5):1031-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:160931 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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