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| Caption | Targeting strategy for the generation of the Klhl40tm1(KOMP)Vlcg allele. The coding sequence of Klhl40 (not including the start codon) as well as 23 nucleotides past the stop codon (nucleotides 172-5816 of NCBI reference sequence NC_000075.6) were replaced with a Beta-galactosidase (LacZ-pA) and neomycin (hUbC-neo) expression cassette. The promoter and the 5' (E1') and 3' (E6') untranslated regions of Klhl40 were left intact allowing for LacZ expression to be driven by the endogenous promoter. Neomycin expression was driven by the human ubiquitin C (hUbC) promoter. Black boxes represent exons and half arrows indicate location of qPCR primers that were used to analyze Klhl40 mRNA. Red triangles denote loxP sites and ATG and TGA/TAA represent translational start and stop sites, respectively. | ||||||
| Copyright | This image is from Garg A, J Clin Invest 2014 Aug 1;124(8):3529-39 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:213780 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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