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| Caption | Generation of the Col2a1mc13 allele. (A) The ENU mutation is in the intron after exon 21 (red). (B) Analysis of the Col2a1 cDNA transcript in this area of the gene indicates an abnormal splice variant in the mutant sample (b2) in addition to the expected PCR product (b1). (C) The b2 PCR product represents an mRNA that does not include all of exon 21, but prematurely transitions to exon 22. (D) The abnormal transcript codes for a premature stop codon in exon 21 which is predicted to translate a protein approximately 30% the length of wild-type. | ||||
| Copyright | This image is from Cionni M, PLoS One 2014;9(12):e116104, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:225386 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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