Molecular Image Detail

Image

Caption

(A) Schematic diagram of the strategy used to generate the Ltf^tm1.1Smoc and Ltf^tm1.2Smoc alleles. (1) Founder mice: Exon 3 of mouse Ltf is flanked by loxp sequences. FRT-flanked neo is located between exon 2 and exon 3. (2) The neo cassette is deleted by crossing the founder mice with transgenic Flp mice generating the Ltf^tm1.1Smoc allele. (3) Exon 3 is deleted by crossing the neo- exon 3+ mice with transgenic EIIa-Cre mice, generating the Ltf^tm1.2Smoc allele. (4) Wild-type (WT) Ltf, which is also generated from the same cross as in (3), has 17 exons. P1 and P2 indicate primers used for PCR analysis.

This image is from Ye Q, PLoS One 2014;9(7):e103298, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:219007

Associated
Alleles

Symbol	Name
Ltf^tm1.1Smoc	lactotransferrin; targeted mutation 1.1, Shanghai Model Organisms Center
Ltf^tm1.2Smoc	lactotransferrin; targeted mutation 1.2, Shanghai Model Organisms Center

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