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| Caption | Generation of the Npr1tm1.1Kkan allele. (A) Schematic representation of the wild-type (WT) allele, the targeted allele and the conditional Npr1tm1.1Kkan allele. Npr1 (GC-A) gene (yellow box) is flanked by two lox P sites (green arrowheads). Together with the first lox P site, a neomycin selection cassette, (gray box), flanked by two frt sites (red arrowheads) has been inserted. Mice carrying the targeted allele were crossed with transgenic mice expressing Flp recombinase under the control of CAG promoter to remove the PKG-Neo-pA cassette, resulting in the Npr1tm1.1Kkan allele. | ||||
| Copyright | This image is from Nojiri T, Proc Natl Acad Sci U S A 2015 Mar 31;112(13):4086-91. Copyright 2015 National Academy of Sciences, U.S.A. J:220676 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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