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| Caption | Generation of the Abi1tm1.1Lko and Abi1tm1.2Lko alleles. A) Design of the targeting vector and subsequent steps of recombinant Abi1 allele modification. Abi1 allele, wild-type allele; targeted allele, the targeting vector containing exon 1 with the short homology arm (SA) extending 3' and the long homology arm (LA) on the 5' side of exon 1. Exon 1 is flanked by two loxP sites, and the neomycin gene cassette is inserted 3' to exon 1 and internal to the distal loxP site. The neomycin gene cassette is bound by two frt sites and includes an additional loxP site. The target region is 0.9 kb and includes exon 1. Floxed allele, the recombinant Abi1 allele following frt-mediated removal of the neomycin cassette, Abi1tm1.1Lko; deleted allele, the recombinant Abi1 allele following Cre-mediated removal of exon 1, Abi1tm1.2Lko. | ||||||
| Copyright | This image is from Dubielecka PM, Proc Natl Acad Sci U S A 2011 Apr 26;108(17):7022-7. Copyright 2011 National Academy of Sciences, U.S.A. J:171342 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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