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| Caption | Generation of the Mtortm1.1Gcon allele. (A) Strategy used to knock out mTOR in mouse cardiomyocytes and generate the Mtortm1.1Gcon allele. Exon 2 and 3 of the mTOR gene was flanked by loxP sites, and a neomycin (Neo) resistance cassette, flanked by FRT sites, inserted upstream. Maps of the wild-type mTOR locus, the targeting vector, the floxed allele (Mtortm1.1Gcon), and the excised allele upon cre-mediated recombination are shown. Exons are shown as boxes. The position of the 3' probes used for Southern blot analysis in B are indicated. Arrows indicate primer positions for PCR. Arrowheads indicate the loxP sites. | ||||
| Copyright | This image is from Zhang D, J Clin Invest 2010 Aug 2;120(8):2805-16 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:163763 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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