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| Caption | Generation of the Ctsltm1.1Thre (CtslKiTTC STOP) and Ctsltm1.2Thre (CtslKiTTCdeltaSTOP) alleles. a) Schematic of the knock-in approach. By homologous recombination of the knock-in cassette with the mouse cathepsin L locus, the M1 ATG was substituted by TTC. Additionally, the knock-in cassette harboured a poly-A signal in intron 2, which abrogates transcription of the allele. As this poly-A signal is flanked by LoxP sites, it can be removed by Cre-recombination. | ||||||
| Copyright | This image is from Tholen M, Nat Commun 2014;5():4931, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:216506 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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