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| Caption | Generation of Hoxc8 conditional loss-of-function alleles, Hoxc8tm1Jepl and Hoxc8tm2Jepl. (a) Hoxc8 genomic locus. E1 and E2 represent Exon1 and 2, yellow boxes represent coding region, purple lines represent the intron, and pink boxes represent the 3' untranslated region (UTR). X = Xba1, H = HindIII, Sp = Sph1, Sc = SacII, N = Nco1, Sl = Sal1, Ea = Ear1. Targeting constructs contain ~9.5-kb genomic DNA from the 5' Sph1 site to the 3' Xba1 site. "IR" represents internal ribosome reentry site, "marker" represents either eGFP or nlsLacZ reporters used in various versions of the targeting constructs. | ||||||
| Copyright | This image is from Blackburn J, Genesis 2009 Jul 20;47(10):680-687, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:153560 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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