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| Caption | Generation of the Gt(ROSA)26Sortm2Nat allele. The R26IAP locus in its germline configuration (upper diagram) and following Cre-mediated recombination (lower diagram). The IAP region is preceded by a splice acceptor so that it can be spliced onto the 5' exon of the endogenous Rosa26 transcript. In the germline configuration, the two loxP sites in head-to-head orientation surround a central region that must be inverted to generate a correctly configured human placental alkaline phosphatase (hPLAP) minigene (lower diagram). In the orientation shown in the lower diagram, one loxP site resides in the intron and the second loxP site resides in the 3' UTR. Scale bars in B and C are 1 Kb. | ||||
| Copyright | This image is from Badea TC, PLoS One 2009;4(11):e7859, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155417 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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