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| Caption | Generation of the Bloc1s1tm1Wli and Bloc1s1tm1.1Wli alleles. B, schematic diagram of gene targeting vector of mouse Bloc1s1. Note that exon 2 is engineered to be deleted by inserting two flanking loxp sites in intron 1 and intron 2 and a neomycin (neo) cassette. Using this gene-targeting strategy, the obtained heterozygous Bloc1s1 knock-out mice (Bloc1s1tm1.1Wli) were generated by crossing Bloc1s1tm1Wli (Bloc1s1loxp/+) mice with EII-Cre mice. Intercross of heterozygous Bloc1s1tm1.1Wli mice produced null mutant mice with exon 2 deletion. | ||||||
| Copyright | This image is from Zhang A, J Biol Chem 2014 Oct 17;289(42):29180-94 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:238911 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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