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| Caption | Generation of the Pcdhatm10Tyag (del(2-11)) allele. A, genomic structure of the Pcdha wild-type (WT) allele. It consists of 14 first exons (white boxes) in the variable region and three CR exons (CR1-CR3, black boxes) in the constant region. The first exons are termed a1-a12, ac1, and ac2, from 5' to 3'. Pcdha genes are produced by splicing each first exon to the CR exons, and termed Pcdha1-Pcdha12, Pcdhac1, and Pcdhac2. DNase I-hypersensitive sites (HS5-1 and HS7) are shown as ovals. Arrows indicate the direction of transcription. F, the del(2-11) allele: deletion of a2-a11. The del(2-11) allele was produced from the G16Neo (Pcdhatm6Tyag) and 11R (Pcdhatm7.1Tyag) allele. The deleted DNA segments are indicated by dashed lines. The loxP sites are shown as blue triangles. | ||||
| Copyright | This image is from Noguchi Y, J Biol Chem 2009 Nov 13;284(46):32002-14 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:156323 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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