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| Caption | Generation of the Pcdhatm9Tyag (dup(12-c2)) allele. A, genomic structure of the Pcdha wild-type (WT) allele. It consists of 14 first exons (white boxes) in the variable region and three CR exons (CR1-CR3, black boxes) in the constant region. The first exons are termed a1-a12, ac1, and ac2, from 5' to 3'. Pcdha genes are produced by splicing each first exon to the CR exons, and termed Pcdha1-Pcdha12, Pcdhac1, and Pcdhac2. DNase I-hypersensitive sites (HS5-1 and HS7) are shown as ovals. Arrows indicate the direction of transcription. H, The dup(12-c2) allele (Pcdhatm9Tyag): duplication of a12-ac2. The dup(12-c2) allele was produced by Cre-loxP-mediated trans-allelic meiotic recombination between the 11R (Pcdhatm7.1Tyag) and G1loxP (Pcdhatm1Tyag) alleles. The duplicated segments are shown under the position of the original segment. The loxP sites are shown as blue triangles. | ||||
| Copyright | This image is from Noguchi Y, J Biol Chem 2009 Nov 13;284(46):32002-14 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:156323 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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