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| Caption | Generation of the Del(16Fam162a-Stfa2l1)1Gusa allele. Representation of the 95-kb haploid chromosomal deletion, Del(16Fam162a-Stfa2l1)1Gusa, found in an ESC clone (730) engineered by a retroviral-based Cre-loxP system. The schema was adapted from UCSC Genome Browser (http://genome.ucsc.edu/). Mammal conservation (blue histogram) represents a evolutionary conservation measure across 20 placental mammal genomes. In addition, 8 pairwise alignments of vertebrate genomes to the mouse genome can be found underneath (greyscale density plots). Also indicated, the recombined provirus originating from the recombination of two independent proviruses (A1 and S1). The coupling of the Pgk (murine phosphoglycerate kinase promoter)-ATG in S1 to the neomycin (neo ATGless) gene in A1 allowed the selection of recombinant ESC clones. LTR, long terminal repeat; SIN, long terminal repeat containing a deletion in the U3 region; black triangle, LoxP site. | ||||
| Copyright | This image is from Bilodeau M, PLoS One 2009;4(10):e7500, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:154051 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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