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| Caption | Generation of the Gdf11tm2.1Sjl and Gdf11tm2.2Sjl alleles. (A) Representation of targeting strategy. The 3 exons are shown as boxes with coding sequences shaded black and the 3'UTR open. The targeting construct is represented by a thick line which contains loxP sequences with EcoRI restriction sites inserted into the second XbaI site in exon 1 and flanking a neo gene inserted into the EcoRI site downstream of the 3'UTR. Cre-mediated recombination of the loxP sites flanking the neo gene results in a Gdf11tm2.1Sjl (Gdf11flox) allele. Recombination of the Gdf11tm2.1Sjl (Gdf11 flox allele) allele generates the Gdf11tm2.2Sjl (Gdf11 delta2-3 allele) allele. Oligonucleotide primers used for distinguishing alleles are labeled a, b, and c. | ||||||
| Copyright | This image is from McPherron AC, BMC Dev Biol 2009;9():24, an open-access article, licensee BioMed Central Ltd. J:158173 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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