Molecular Image Detail

Image

Caption

Generation of the Ptpn11^tm4.2Bgn allele. (A) Structure of the Ptpn11 targeting locus and targeting construct region. Protein coding regions, LoxP sites, and Frt sites are shown. The arrows highlight the target positions of PCR primers used to identify homologous recombinants. Note that primers PLF and PRR are outside the region of homology. The expected amplicons are indicated with brackets and are specific to homologously recombined templates. LoxP sites are shown as black triangles; mutant LoxP511 sites are shown as white triangles. Their relative orientation is shown by the orientation of the triangles. FRT sites are shown as white ovals. Exons are indicated by rectangles. (B) Structure of locus after Flp-mediated recombination. (C) Structure of locus after Cre-mediated recombination.

This image is from Marin TM, J Clin Invest 2011 Mar 1;121(3):1026-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172033

Associated
Alleles

Symbol	Name
Ptpn11^tm4.2Bgn	protein tyrosine phosphatase, non-receptor type 11; targeted mutation 4.2, Benjamin G Neel

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