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| Caption | Generation of the Anp32btm1Mak allele. (A) Targeting of the murine Anp32b gene. (Top) Murine genomic Anp32b locus showing exons and regions of homology (gray). FP: flanking probe detecting intron 1. H: HindIII; E: EagI sites. The translation start site (ATG) and stop sites are shown. (Middle) Targeting construct that replaced exons 2-4 with a pgk-neo cassette. DTA: diphtheria toxin A sequence for negative selection. (Bottom) Targeted Anp32b allele. Diagnostic HindIII fragments for the WT Anp32b allele (5.4 kb) and the targeted Anp32b allele (5.2 kb), as well as the diagnostic EagI fragment for neo insertion (8.3 kb) are shown. | ||||
| Copyright | This image is from Reilly PT, Proc Natl Acad Sci U S A 2011 Jun 2;108(25):10243-8. Copyright 2011 National Academy of Sciences, U.S.A. J:172042 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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