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| Caption | Generation of the Mglltm1.1Rzim allele. Targeting strategy for the generation of the Mglltm1.1Rzim allele. a, Homologous recombination of the targeting vector with the wild-type allele resulted in the introduction of a loxP site into intron 4 and a neomycin resistance gene cassette flanked by loxP sites into intron 2 of the gene. Subsequent Cre-recombinase-mediated recombination among the distal loxP sites resulted in the deletion of exon 3 and 4. The targeted allele was identified by KpnI (K) restriction digest and hybridization with an external Southern probe (solid bar) revealing a 7.0-kb DNA fragment. | ||||
| Copyright | This image is from Taschler U, J Biol Chem 2011 May 20;286(20):17467-77 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:172679 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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