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| Caption | Generation of the Zbtb46tm1Kmm allele. (A) The endogenous mouse Zbtb46 locus (top) contains five exons, with the first exon entirely noncoding and the second exon containing the methionine initiation codon and encoding the BTB domain of Zbtb46 (line). The Zbtb46 locus, the targeting vector, and mutant allele with retention of the neomycin (pGK-Neo) selection cassette are shown. Exons are displayed as boxes, with coding regions shaded. Double digestion of the germline locus with KpnI (K) and BamHI (B) yields a restriction fragment of 13.8 kB, which is detected by both the 5' probe and 3' probe. Correctly targeted clones show an additional 7.3-kB band detected by the 5' probe and a 6.2-kB band detected by the 3' probe. Triangles indicate LoxP sequences. DTA, diphtheria toxin A; pA, polyadenylation signal; TK, thymidine kinase promoter. | ||||
| Copyright | This image is from Satpathy AT, J Exp Med 2012 Jun 4;209(6):1135-52, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:184205 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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