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| Caption | (a) Targeting strategy for the Sox17tm3.1Heli (Sox17SCF) allele. A targeting vector was used to fuse the coding region of the fluorescent reporter gene mCherry to the open reading frame (orange boxes) of the Sox17 gene. The loxP-flanked neomycin (neo) selection cassette was removed by Cre recombinase-mediated excision. 5'- and 3'-UTRs are indicated by black boxes and the predicted promoter regions (yellow boxes) as well as the two transcriptional start region (TSR, red boxes) are indicated. Primers used for PCR genotyping are designated EP400, EP401, EP420, and EP422. The location of the external 5' probe is indicated and restriction enzyme sites for EcoRV are shown. Homology regions to generate the targeting constructs are indicated as 5' and 3' retrieval in the scheme of the targeting vector. | ||||
| Copyright | This image is from Burtscher I, Genesis 2012 Jun;50(6):496-505, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:185482 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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