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| Caption | (A) Schematic representation of the vector used to generate the Z/Lhx2-green fluorescent protein (GFP) transgenic mouse strain, Tg(CAG-Bgeo/Lhx2,-GFP)#Lcar (upper panel) and the organisation of this vector after Cre-mediated recombination (lower panel). The blue arrows correspond to the mRNA that is generated before and after Cre-mediated recombination of this vector. The expression system is based on the Z/alkaline phosphatase (AP) double reporter vector developed by Lobe and co-workers, where a floxed allele of beta-Geo (encoding a beta-galactosidase-Neomycin fusion protein) is followed by an expression cassette consisting of the Lhx2 cDNA, an internal ribosomal entry site (IRES) and GFP cDNA. Thus, DNA recombination by the Cre recombinase will delete the beta-Geo gene and place Lhx2-GFP immediately downstream of the promoter/enhancer leading to its transcription. We generated a mouse strain transgenic for this vector that showed beta-Gal activity in a variety of tissues including epidermis. | ||||
| Copyright | This image is from Tornqvist G, PLoS Genet 2010;6(4):e1000904, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:159209 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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