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| Caption | Generation of the Masp2tm1Wjsc allele. (A) Masp2 was disrupted by homologous recombination in embryonic stem (ES) cells using a Masp2 specific targeting construct established in the vector pKO-NTKV 1901. The construct replaces exon 11 (encoding the C-terminal part of the CCP-2 domain), intron 11, and the start of exon 12 (encoding the serine protease domain) with the PGK-Neo cassette, inserting frame-shift mutations and deleting 122 bp of coding sequence, including that for the essential residues for serine protease activity. | ||||
| Copyright | This image is from Schwaeble WJ, Proc Natl Acad Sci U S A 2011 May 3;108(18):7523-8. Copyright 2011 National Academy of Sciences, U.S.A. J:172218 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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