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Caption Generation of the Shox2tm2(SHOX_a)Ypc (Shox2KI-neo) allele. Targeted replacement of the mouse Shox2 locus with human SHOXa cDNA. A, the Shox2 gene contains six exons that span ~8.3 kb of genomic DNA. Exons 1-5 are shown as blue boxes. The position of the translation start codon (ATG) is indicated. The targeting vector used the 5.6-kb fragment upstream to the ATG codon as the 5' homology arm and a 2.9-kb fragment after exon 2 as the 3' arm, as indicated by the dashed lines. The human SHOXa cDNA and a FTR-flanked PGK-neo cassette were inserted in between the arms and a diphtheria toxin A (DTA) expression cassette was cloned 5' to the 5' arm for negative selection. The 5' and 3' probes used for Southern blotting were indicated by short lines.
Copyright This image is from Liu H, J Biol Chem 2011 May 13;286(19):17029-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:172674
Associated
Alleles
Symbol Name
Shox2tm2(SHOX_a)Ypc SHOX homeobox 2; targeted mutation 2, YiPing Chen

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory