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| Caption | Generation of the Shox2tm2(SHOX_a)Ypc (Shox2KI-neo) allele. Targeted replacement of the mouse Shox2 locus with human SHOXa cDNA. A, the Shox2 gene contains six exons that span ~8.3 kb of genomic DNA. Exons 1-5 are shown as blue boxes. The position of the translation start codon (ATG) is indicated. The targeting vector used the 5.6-kb fragment upstream to the ATG codon as the 5' homology arm and a 2.9-kb fragment after exon 2 as the 3' arm, as indicated by the dashed lines. The human SHOXa cDNA and a FTR-flanked PGK-neo cassette were inserted in between the arms and a diphtheria toxin A (DTA) expression cassette was cloned 5' to the 5' arm for negative selection. The 5' and 3' probes used for Southern blotting were indicated by short lines. | ||||
| Copyright | This image is from Liu H, J Biol Chem 2011 May 13;286(19):17029-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:172674 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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