Molecular Image Detail

Image

Caption

Generation of the Adam10^tm1.1Dhc allele. A targeting vector containing intron 8, exon 9, and intron 9 of mouse Adam10 , and loxP (gray triangles) and FRT (open triangles) sites were inserted into the Adam10 gene via homologous recombination to generate an ADAM10 ^flox allele. Removal of the Neo cassette via Flp1-mediated recombination generated Adam10^tm1.1Dhc (ADAM10^delta), containing exon 9 flanked by loxP sites. Cre-mediated recombination can be used to conditionally remove exon 9. Primers P1 and P2 amplify a 955-bp sequence of nonrecombined ADAM10^delta or a 217-bp sequence of the recombined allele, respectively.

This image is from Gibb DR, J Exp Med 2010 Mar 15;207(3):623-35, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:158127

Associated
Alleles

Symbol	Name
Adam10^tm1.1Dhc	a disintegrin and metallopeptidase domain 10; targeted mutation 1.1, Daniel H Conrad

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