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| Caption | Generation of the Slc39a5tm1Gka and Slc39a5tm1.1Gka alleles. Structures of the pre- (Slc39a5tm1Gka) and post-cre (Slc39a5tm1.1Gka) floxed mouse Slc39a5 (Zip5) gene and integration and genotyping screen designs. (A) The mouse gene was captured using gap-repair and manipulated using galK recombineering. Exons (1-12) and the exon encoding transmembrane domain 1 (TMD1) are indicated, as are the positions of LoxP sites (intron 4 and downstream of PGK Neo), the PGK-neomycin (PGK Neo) cassette and the locations of primers used for genotyping. The LoxP site in intron 4 is flanked by an EcoRV restriction enzyme cleavage site. (B) The structure of the Slc39a5 gene after cre recombination is shown. Recombination eliminates the transmembrane domain of Slc39a5 and generates the Slc39a5tm1.1Gka allele. | ||||||
| Copyright | This image is from Geiser J, PLoS One 2013;8(11):e82149, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209760 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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