Molecular Image Detail

Image

Caption

A: Strategy for targeted manipulation of the Crhr1 locus. Partial restriction maps of wild-type Crhr1 locus; targeting vector; recombined reporter alleles with (Crhr1^tm2Jde [Crhr1^tZ]) and without (Crhr1^tm2.1Jde [Crhr1^deltatZ]) endogenous signal peptide after Cre-mediated excision of the respective loxP-flanked sequence; recombined allele (Crhr1^tm2.2Jde [Crhr1^flox]) following removal of the FRT flanked reporter-selection cassette and knockout allele (Crhr1^tm2.3Jde [Crhr1^-]) following Cre-mediated excision of the loxP-flanked exon 2.

This image is from Kuhne C, J Comp Neurol 2012 Oct 1;520(14):3150-80, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:187372

Associated
Alleles

Symbol	Name
Crhr1^tm2.1Jde	corticotropin releasing hormone receptor 1; targeted mutation 2.1, Jan Deussing
Crhr1^tm2.2Jde	corticotropin releasing hormone receptor 1; targeted mutation 2.2, Jan Deussing
Crhr1^tm2.3Jde	corticotropin releasing hormone receptor 1; targeted mutation 2.3, Jan Deussing
Crhr1^tm2Jde	corticotropin releasing hormone receptor 1; targeted mutation 2, Jan Deussing

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