Molecular Image Detail

Image

Caption

Generation of the Slc6a8^tm1Clar, Slc6a8^tm1.1Clar, and Slc6a8^tm1.2Clar alleles. (A) Strategy for recombination and deletion of Slc6a8. The structure of the wild-type Slc6a8 locus, the targeted locus after recombination in embryonic stem cells (Slc6a8^tm1Clar), and the floxed allele after Flp-mediated deletion of the neo cassette (Slc6a8^tm1.1Clar) are shown. Cre expression results in deletion of exons 2-4 (E2-E4) and generates the Slc6a8^tm1.2Clar allele. Exons are denoted by boxes; neo, loxP sequences, and FRT sequences are denoted by triangles.

This image is from Kurosawa Y, J Clin Invest 2012 Aug 1;122(8):2837-46 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190081

Associated
Alleles

Symbol	Name
Slc6a8^tm1.1Clar	solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.1, Joseph Clark
Slc6a8^tm1.2Clar	solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.2, Joseph Clark
Slc6a8^tm1Clar	solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1, Joseph Clark

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