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| Caption | Generation of the Tg(CD19-cre/ERT2)1Jsv transgene. Schematic representation of the hCD19-CreERT2 construct. The DNA fragment encoding CreERT2 was placed downstream of a 6.3-kb fragment of the human CD19 promoter. The construct was then cloned into the multiple cloning site (MCS) of the pE11.F3.M.F. shuttle vector, followed by homologous recombination into the LC-1 BAC clone via lambda red recombination. The linearized BAC clone of 75 kb was used to generate transgenic animals (BAC, bacterial articifial chromosome; MCS, multiple cloning site; FRT, recognition site for Flp recombinase; HA-A and B, homologous arm A and B; bgHpA, bovine growth hormone polyA; Amp, ampicilline; CA, chloramphenicol). | ||||
| Copyright | This image is from Boross P, Genesis 2009 Nov;47(11):729-35, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:154796 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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